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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1897 1
1900 1
1920 1
1921 1
1927 1
1928 1
1930 1
1950 1
1953 1
1955 1
1956 1
1957 1
1958 1
1959 1
1960 1
1961 3
1962 3
1964 3
1965 2
1966 4
1967 3
1968 2
1969 3
1970 5
1971 5
1972 7
1973 7
1974 15
1975 65
1976 57
1977 58
1978 48
1979 73
1980 50
1981 70
1982 56
1983 114
1984 113
1985 140
1986 116
1987 129
1988 150
1989 186
1990 187
1991 174
1992 186
1993 160
1994 185
1995 173
1996 200
1997 201
1998 203
1999 202
2000 186
2001 205
2002 223
2003 208
2004 241
2005 249
2006 283
2007 263
2008 274
2009 306
2010 383
2011 360
2012 411
2013 419
2014 427
2015 482
2016 479
2017 520
2018 540
2019 641
2020 752
2021 868
2022 987
2023 1048
2024 391

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13,297 results

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Page 1
Identification of Enteroendocrine Regulators by Real-Time Single-Cell Differentiation Mapping.
Gehart H, van Es JH, Hamer K, Beumer J, Kretzschmar K, Dekkers JF, Rios A, Clevers H. Gehart H, et al. Cell. 2019 Feb 21;176(5):1158-1173.e16. doi: 10.1016/j.cell.2018.12.029. Epub 2019 Jan 31. Cell. 2019. PMID: 30712869 Free article.
We resolved transcriptional changes during enteroendocrine differentiation in real time at single-cell level using a novel knockin allele of Neurog3, the master regulator gene briefly expressed at the onset of enteroendocrine specification. A bi-fluorescent reporter …
We resolved transcriptional changes during enteroendocrine differentiation in real time at single-cell level using a novel kno …
Absolute quantification of protein number and dynamics in single cells.
Royer CA, Tyers M, Tollis S. Royer CA, et al. Curr Opin Struct Biol. 2023 Oct;82:102673. doi: 10.1016/j.sbi.2023.102673. Epub 2023 Aug 16. Curr Opin Struct Biol. 2023. PMID: 37595512 Review.
Here, we review the merits and pitfalls of different quantitative fluorescence imaging methods for single-cell determination of protein abundance, localization, interactions, and dynamics. ...
Here, we review the merits and pitfalls of different quantitative fluorescence imaging methods for single-cell determination of prote …
A single-cell resolution map of mouse hematopoietic stem and progenitor cell differentiation.
Nestorowa S, Hamey FK, Pijuan Sala B, Diamanti E, Shepherd M, Laurenti E, Wilson NK, Kent DG, Göttgens B. Nestorowa S, et al. Blood. 2016 Aug 25;128(8):e20-31. doi: 10.1182/blood-2016-05-716480. Epub 2016 Jun 30. Blood. 2016. PMID: 27365425 Free PMC article.
Because cell fate choices are executed at the individual cell level, new single-cell profiling technologies offer exciting possibilities for mapping the dynamic molecular changes underlying HSPC differentiation. ...By using external spike-in controls, …
Because cell fate choices are executed at the individual cell level, new single-cell profiling technologies offer excit …
Mitochondrial Dynamics and Cristae Shape Changes During Metabolic Reprogramming.
Kawano I, Bazila B, Ježek P, Dlasková A. Kawano I, et al. Antioxid Redox Signal. 2023 Oct;39(10-12):684-707. doi: 10.1089/ars.2023.0268. Epub 2023 Sep 19. Antioxid Redox Signal. 2023. PMID: 37212238 Review.
Significance: The architecture of the mitochondrial network and cristae critically impact cell differentiation and identity. Cells undergoing metabolic reprogramming to aerobic glycolysis (Warburg effect), such as immune cells, stem cells, and cancer cells, go throu …
Significance: The architecture of the mitochondrial network and cristae critically impact cell differentiation and identity. C …
Interspecies control of development during mammalian gastrulation.
Simpson L, Alberio R. Simpson L, et al. Emerg Top Life Sci. 2023 Dec 18;7(4):397-408. doi: 10.1042/ETLS20230083. Emerg Top Life Sci. 2023. PMID: 37933589 Free PMC article. Review.
These studies highlight conserved cell differentiation regulators and both absolute and relative differences in differentiation dynamics between species. ...This scaling is likely due to intrinsic differences in cell biochemistry. We also highli …
These studies highlight conserved cell differentiation regulators and both absolute and relative differences in diff …
Sources of beta cells inside the pancreas.
De Groef S, Staels W, Van Gassen N, Lemper M, Yuchi Y, Sojoodi M, Bussche L, Heremans Y, Leuckx G, De Leu N, Van de Casteele M, Baeyens L, Heimberg H. De Groef S, et al. Diabetologia. 2016 Sep;59(9):1834-7. doi: 10.1007/s00125-016-3879-6. Epub 2016 Apr 6. Diabetologia. 2016. PMID: 27053238 Review.
The generation of beta(-like) cells to compensate for their absolute or relative shortage in type 1 and type 2 diabetes is an obvious therapeutic strategy. Patients first received grafts of donor islet cells over 25 years ago, but this procedure has not become routine in c …
The generation of beta(-like) cells to compensate for their absolute or relative shortage in type 1 and type 2 diabetes is an obvious …
Pancreas cell fate.
Guney MA, Gannon M. Guney MA, et al. Birth Defects Res C Embryo Today. 2009 Sep;87(3):232-48. doi: 10.1002/bdrc.20156. Birth Defects Res C Embryo Today. 2009. PMID: 19750517 Free PMC article. Review.
Diabetes is characterized by decreased function of insulin-producing beta cells and insufficient insulin output resulting from an absolute (Type 1) or relative (Type 2) inadequate functional beta cell mass. ...A thorough understanding of the normal developmental pro …
Diabetes is characterized by decreased function of insulin-producing beta cells and insufficient insulin output resulting from an absolut …
Absolute Quantification of Transcription Factors Reveals Principles of Gene Regulation in Erythropoiesis.
Gillespie MA, Palii CG, Sanchez-Taltavull D, Shannon P, Longabaugh WJR, Downes DJ, Sivaraman K, Espinoza HM, Hughes JR, Price ND, Perkins TJ, Ranish JA, Brand M. Gillespie MA, et al. Mol Cell. 2020 Jun 4;78(5):960-974.e11. doi: 10.1016/j.molcel.2020.03.031. Epub 2020 Apr 23. Mol Cell. 2020. PMID: 32330456 Free PMC article.
Dynamic cellular processes such as differentiation are driven by changes in the abundances of transcription factors (TFs). ...These analyses provide a unique quantitative framework to understand transcriptional regulation of cell differentiation in a dynamic …
Dynamic cellular processes such as differentiation are driven by changes in the abundances of transcription factors (TFs). ...These a …
Absolute quantification of transcription factors in human erythropoiesis using selected reaction monitoring mass spectrometry.
Gillespie MA, Palii CG, Sanchez-Taltavull D, Perkins TJ, Brand M, Ranish JA. Gillespie MA, et al. STAR Protoc. 2020 Dec 13;1(3):100216. doi: 10.1016/j.xpro.2020.100216. eCollection 2020 Dec 18. STAR Protoc. 2020. PMID: 33377109 Free PMC article.
Quantitative changes in transcription factor (TF) abundance regulate dynamic cellular processes, including cell fate decisions. Protein copy number provides information about the relative stoichiometry of TFs that can be used to determine how quantitative changes in TF abu …
Quantitative changes in transcription factor (TF) abundance regulate dynamic cellular processes, including cell fate decisions. Prote …
The progress of pluripotent stem cell-derived pancreatic beta-cells regeneration for diabetic therapy.
Wang X, Gao M, Wang Y, Zhang Y. Wang X, et al. Front Endocrinol (Lausanne). 2022 Jul 28;13:927324. doi: 10.3389/fendo.2022.927324. eCollection 2022. Front Endocrinol (Lausanne). 2022. PMID: 35966093 Free PMC article. Review.
Diabetes is a complex metabolic disorder of carbohydrate metabolism, characterized by high blood glucose levels either due to an absolute deficiency of insulin secretion or an ineffective response of cells to insulin, a hormone synthetized by beta-cells in the pancreas. .. …
Diabetes is a complex metabolic disorder of carbohydrate metabolism, characterized by high blood glucose levels either due to an absolute …
13,297 results
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